2006年细胞因子相关论文排行榜

　　Ion Channel Media Group（www.ionchannels.org）根据通过其cytokine portal入口检索细胞因子相关文章的访问数量排列出了2006年细胞因子领域最有影响力的文章，这一排名除了参考了公众的访问情况(popularity score)之外，也考虑引用情况（citation score）——包括杂志期刊的引用情况和原创作者的引用情况。

　　

生物通报道：Ion Channel Media Group（www.ionchannels.org）根据通过其cytokine portal入口检索细胞因子相关文章的访问数量排列出了2006年细胞因子领域最有影响力的文章，这一排名除了参考了公众的访问情况(popularity score)之外，也考虑引用情况（citation score）——包括杂志期刊的引用情况和原创作者的引用情况。

排名文章见下：

 Chang et al. (2006) The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFalpha-induced Cell Death by Inducing c-FLIP(L) Turnover. Cell

Li et al. (2006) TRANSFORMING GROWTH FACTOR-beta REGULATION OF IMMUNE RESPONSES. Annu Rev Immunol

Fehérvari et al. (2006) The dichotomous role of IL-2: tolerance versus immunity. Trends Immunol

Jones et al. (2006) Regulation of cancer cell migration and bone metastasis by RANKL. Nature

Janes et al. (2006) The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine Cascade. Cell

Ansel et al. (2006) Regulation of Th2 Differentiation and Il4 Locus Accessibility. Annu Rev Immunol

Barber et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature

Zhang et al. (2006) Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response. Cell

Mangan et al. (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature

Gallagher et al. (2006) Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol

Ansel et al. (2006) REGULATION OF TH2 DIFFERENTIATION AND Il4 LOCUS ACCESSIBILITY. Annu Rev Immunol

Gallagher et al. (2006) Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A

Rothenberg et al. (2006) The eosinophil. Annu Rev Immunol

Wu et al. (2006) FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT. Cell

Kim et al. (2006) Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature

Uematsu et al. (2006) Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c(+) lamina propria cells. Nat Immunol

Blom et al. (2006) Development of human lymphoid cells. Annu Rev Immunol

Sutterwala et al. (2006) Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1. Immunity

Ogura et al. (2006) The inflammasome: first line of the immune response to cell stress. Cell

Kawai et al. (2006) Innate immune recognition of viral infection. Nat Immunol

Tedgui et al. (2006) Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev

Kahn et al. (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature

Liu et al. (2006) TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation. Annu Rev Immunol

Bergamaschi et al. (2006) Synergistic effects of cAMP-dependent signalling pathways and IL-1 on IL-6 production by H19-7/IGF-IR neuronal cells. Cell Signal

Ma et al. (2006) Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol

Laiosa et al. (2006) Determinants of lymphoid-myeloid lineage diversification. Annu Rev Immunol

Balboni et al. (2006) MULTIPLEXED PROTEIN ARRAY PLATFORMS FOR ANALYSIS OF AUTOIMMUNE DISEASES. Annu Rev Immunol
Fujii et al. (2006) Glycolipid {alpha}-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci U S A

Di Santo et al. (2006) NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance. Annu Rev Immunol

Suntharalingam et al. (2006) Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412. N Engl J Med

Carty et al. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol

Trautmann et al. (2006) Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction. Nat Med

van Loo et al. (2006) Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol

Gilchrist et al. (2006) Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature

Stumhofer et al. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol

Uhlig et al. (2006) Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology. Immunity

Cooper et al. (2006) Characterization of STAT5B phosphorylation correlating with expression of cytokine-inducible SH2-containing protein (CIS). Cell Signal

Creagh et al. (2006) TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol

Vosshenrich et al. (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol

Takahashi et al. (2006) Cutting edge: roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol

Groh et al. (2006) Fas ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat Immunol

et al. (2006) Cytokine analysis to predict immunosuppression. Cytometry A

Weaver et al. (2006) Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity

Okada et al. (2006) Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med

Ohteki et al. (2006) Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med

Kinjyo et al. (2006) Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-{beta}1. J Exp Med

Liang et al. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med

Kaisho et al. (2006) Toll-like receptor function and signaling. J Allergy Clin Immunol

Hsu et al. (2006) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol

Yu et al. (2006) Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells. Immunity

Stellwagen et al. (2006) Synaptic scaling mediated by glial TNF-alpha. Nature

Langowski et al. (2006) IL-23 promotes tumour incidence and growth. Nature

Ugocsai et al. (2006) Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages. Cytometry A

Scheu et al. (2006) Activation of the integrated stress response during T helper cell differentiation. Nat Immunol

Lee et al. (2006) T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics. Immunity

Sutmuller et al. (2006) Toll-like receptors on regulatory T cells: expanding immune regulation. Trends Immunol

O'hara et al. (2006) Cell-surface and cytokine biomarkers in autoimmune and inflammatory diseases. Drug Discov Today

Klemm et al. (2006) The Bcl10-Malt1 complex segregates Fc{varepsilon}RI-mediated nuclear factor {kappa}B activation and cytokine production from mast cell degranulation. J Exp Med

Anderwald et al. (2004) Adipotoxicity and the insulin resistance syndrome. Pediatr Endocrinol Rev

Chi et al. (2006) Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A

Trumpfheller et al. (2006) Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med

Girgenrath et al. (2006) TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J

Zaiss et al. (2006) Amphiregulin, a TH2 Cytokine Enhancing Resistance to Nematodes. Science

Choi et al. (2006) Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat Immunol

Chen et al. (2006) Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest

Babon et al. (2006) The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability. Mol Cell

Pedraz et al. (2005) [Cutaneous marginal zone B-cell lymphoma treated with rituximab] Actas Dermosifiliogr

Beadling et al. (2006) Quantifying viable virus-specific T cells without a priori knowledge of fine epitope specificity. Nat Med

Joosten et al. (2006) IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci U S A

Cumberbatch et al. (2006) Impaired Langerhans cell migration in psoriasis. J Exp Med

Bertelsen et al. (2006) TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation. Cell Signal

Jack et al. (2006) Activated stress response pathways within multicellular aggregates utilize an autocrine component. Cell Signal

Martínez-Escribano et al. (2005) [Prospective study of the levels of serum cytokines in patients with melanoma: prognostic value] Actas Dermosifiliogr

Kuzushita et al. (2006) Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens. Gastroenterology

Rocha-Campos et al. (2006) Genetic and Functional Analysis of the Nkt1 Locus Using Congenic NOD Mice: Improved V{alpha}14-NKT Cell Performance but Failure to Protect Against Type 1 Diabetes. Diabetes

Inoue et al. (2006) Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A

Yen et al. (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest

Cordova et al. (2006) Effects of AM3 (Inmunoferon(R)) on increased serum concentrations of interleukin-6 and tumour necrosis factor receptors I and II in cyclists. J Sports Sci

Turner et al. (2006) The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms. Cell Signal

Sanjuan et al. (2006) CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion. J Cell Biol

Simmons et al. (2006) What makes a good anti-inflammatory drug target? Drug Discov Today

Wan et al. (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol

Meazza et al. (2004) Effect of growth hormone (GH) on the immune system. Pediatr Endocrinol Rev

von Gunten et al. (2006) Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytes. FASEB J

Monticelli et al. (2005) Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes. Novartis Found Symp

Aggarwal et al. (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol

Dubey et al. (2006) Anti-inflammatory action of diltiazem in patients with unstable angina. Postgrad Med J

Viola et al. (2006) T cells and their partners: the chemokine dating agency. Trends Immunol

Tuncman et al. (2006) Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A

Dinarello et al. (2006) Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am J Clin Nutr

Lohr et al. (2006) Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med

Takada et al. (2006) Acetyl-11-Keto-beta-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-{kappa}B and NF-{kappa}B-Regulated Gene Expression. J Immunol

Leoni et al. (2006) The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med

Alvarez et al. (2006) Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc

Kikly et al. (2006) The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol

Porcellini et al. (2006) Regulation of peripheral T cell activation by calreticulin. J Exp Med

Takeda et al. (2006) Relationship of Serum Advanced Glycation End Products With Deterioration of Periodontitis in Type 2 Diabetes Patients. J Periodontol

Bodor et al. (2006) Regulatory T cell-mediated suppression: potential role of ICER. J Leukoc Biol

Veldhoen et al. (2006) TGFbeta1, a 'Jack of all trades': the link with pro-inflammatory IL-17-producing T cells. Trends Immunol

Clerici et al. (1997) Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression. Cell Death Differ
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