Neuron：解析抑郁症治疗新动向

　　德州大学西南医学研究中心的科学家抗抑郁症最新研究发现，抗抑郁症药物必须促进脑部产生新的神经细胞才能起预期的效果，而抗抑郁治疗的另一方法，运动疗法同样需要刺激脑部产生新的神经元才具有抗抑郁的功效。

　　

 

原文摘要：TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

【Abstract】

Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in the dentate gyrus (DG) that are capable of continuous proliferation and neuronal differentiation are the source of such structural plasticity. Here we report that mice lacking the receptor tyrosine kinase TrkB in hippocampal NPCs have impaired proliferation and neurogenesis. When exposed to chronic ADs or wheel-running, no increase in proliferation or neurogenesis is observed. Ablation of TrkB also renders these mice behaviorally insensitive to antidepressive treatment in depression- and anxiety-like paradigms. In contrast, mice lacking TrkB only in differentiated DG neurons display typical neurogenesis and respond normally to chronic ADs. Thus, our data establish an essential cell-autonomous role for TrkB in regulating hippocampal neurogenesis and behavioral sensitivity to antidepressive treatments, and support the notion that impairment of the neurogenic niche is an etiological factor for refractory responses to an antidepressive regimen.

（生物通 张欢）