首例猪肾脏异种移植实现人体生理稳态：突破性研究为器官短缺危机提供新方案

　　《自然-通讯》近日报道了全球首例活体人类接受基因编辑猪肾脏移植后长达51天的生理功能观察。本研究针对终末期肾病(ESKD)供体器官严重短缺的全球性难题，首次证实经过69处基因编辑的猪肾脏异种移植能够维持人体关键生理功能，包括废物清除、电解质调节和尿液浓缩能力。研究团队通过多维度监测发现移植肾可实现肌酐清除率64 mL/min/1.73 m2，同时揭示了钠离子重吸收、尿酸代谢和磷酸盐调控等方面的特殊生理现象。这项里程碑研究为推进异种移植临床应用提供了关键科学依据，标志着异种移植领域向解决器官短缺危机迈出了实质性一步。

　　

在全球医疗领域，终末期肾病(ESKD)始终是一个严峻的挑战。仅在美国就有超过3500万成年人患有慢性肾脏病(CKD)，其中近80万人进展为肾衰竭。虽然肾移植是目前最理想的治疗方式，但 donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor kidneys far exceeds supply—— donor 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